The degradation by GUT-70 of Hsp90 client proteins, such as Raf-1 and its downstream ERK1/2 and phospho ERK1/2, as well as Akt (Pratt and Toft, 2003; Zhang et al, 2004, 2005), was detected by western blot analysis in all tested MCL cells (Figure 3A). This evidence concerns the gene AKT1 and mantle cell lymphoma.