Increased IL-1α expression correlated with the expression of prometastatic (IL-6 and IL-8) and anti-apoptotic genes (TRAF-1 and cIAP-2) (Bhat-Nakshatri et al, 1998; Newton et al, 1999; Patel et al, 2000) and is associated with invasive and metastatic cancer leading to poor prognosis (Miller et al, 2000). The gene discussed is TRAF1; the disease is metastatic malignant neoplasm.