Therefore, it is possible that high levels of leptin found in the tumour microenvironment, derived either from tumour or adipose cells, can upregulate the expression of Ob-R by tumour cells leading to the increase of tumour growth (Otvos et al, 2008) and expression of pro-angiogenic and inflammatory factors (Guagnano et al, 2003). The gene discussed is LEPR; the disease is neoplasm.