Despite that both leptin (Caldefie-Chézet et al, 2005; Gonzalez et al, 2006; Rene Gonzalez et al, 2009; Gonzalez-Perez et al, 2010; Guo et al, 2010) and IL-1 systems (Kumar et al, 2003; Voronov et al, 2003) seem to have important roles in tumour angiogenesis and growth no published data is available on the potential relationships between leptin and IL-1 signalling in breast cancer. The gene discussed is IL1B; the disease is breast cancer.