The most common indications, for which lung transplantation is performed, include cases of respiratory failure such as chronic obstructive pulmonary disease, cystic fibrosis (mucoviscidosis), idiopathic pulmonary fibrosis, idiopathic pulmonary hypertension, alpha-1 antitrypsin deficiency, bronchiestasis, and sarcoidosis [2]. The gene discussed is SERPINA1; the disease is cystic fibrosis.