It was recently demonstrated that SB transposon-mediated delivery of the myogenic PAX3 transcription factor into iPSCs coaxed their differentiation into MyoD+ myogenic progenitors and multinucleated myofibers [137], suggesting that PAX3 may serve as a myogenic 'molecular switch' in iPSCs, a finding that has implications for cell therapy of congenital degenerative muscle diseases, including Duchenne muscular dystrophy. Here, PAX3 is linked to Duchenne muscular dystrophy.