In recent years CRP values, as measured by a high-sensitivity assay (hs-CRP), have been recognised as a useful and sensitive predictor of the future risk of myocardial infarction and stroke.17 Pepys and Hirschfield14 noted that CRP values cannot be used diagnostically, but should be interpreted with full knowledge of all other clinical and pathological results. The gene discussed is CRP; the disease is myocardial infarction.