According to the 2010 Canadian Thoracic Society's Asthma Management Continuum, omalizumab can be used for "patients with difficult-to-control asthma confirmed with objective measures, who have documented allergies to a perennial aeroallergen, a serum IgE level of 30 IU/mL to 700 IU/mL and whose asthma symptoms remain uncontrolled despite adherence to high-dose inhaled corticosteroids plus at least one additional controller therapy [16]." The gene discussed is IGHE; the disease is asthma.