We have shown that the RT-qPCR-based multi-marker analysis using the six genes: CCNE2, DKFZp762E1312, EMP2, MAL2, PPIC, or SLC6A8 more than doubled the number of positive patients with recurrent breast cancer compared to the analysis of hMAM or EpCAM gene expression alone. This evidence concerns the gene EMP2 and breast cancer.