Between HL cases and controls, estimated frequencies of TLR9/1237C-2848A and MYD88/938C-1944G haplotypes were significantly different (P < .01), as were observed TLR9/1237C-TLR9/2848A-MYD88/938C-MYD88/1944C haplotype differences between the two groups (P < .01). This evidence concerns the gene TLR9 and Hodgkins lymphoma.