Hjalgrim et al. investigated the association between HLA-A*01 and HLA-A*02 in the setting of infectious mononucleosis (IM) and EBV-related HL to determine whether or not HLA class-I restricted EBV-specific cytotoxic T-cell responses and early immune response to EBV infection in IM affect pathogenesis of EBV-related HL [56]. This evidence concerns the gene HLA-A and infectious mononucleosis.