CHL and NLPHL share similar frequency of large malignant cells in an inflammatory background, but unlike CHL, the malignant cells in NLPHL are generally negative for CD30 and CD15 and express the usual B cell-markers CD20 and CD19 as well as normal levels of panhematopoietic marker CD45 [5]. The gene discussed is TNFRSF8; the disease is classic Hodgkin lymphoma.