Others have reported in candidiasis that TLR1 deficient mice had no altered phenotype, whereas TLR6-deficient mice produced similar levels of TNF, IL-1 and IL-6, but less IFNγ and IL-10, providing further evidence that some genes may be regulated specifically by TLR2/TLR6-receptor heterodimers [57], although from thorough studies in cell culture it was concluded that TLR1 and TLR6 lead to identical signaling events [58]. This evidence concerns the gene IL6 and Candidiasis, Invasive.