None of these additional candidates linked to ERα tumor status, or those linked to an early age of diagnosis above, showed significant expression differences at early stages of breast carcinogenesis as EPHB1. On the other hand, the remaining SNPs examined in this study after applying quality controls and Hardy-Weinberg equilibrium analysis (i.e., 10 out of 16), did not show significant associations following CGEMS evidence (Table S3). The gene discussed is ESR1; the disease is neoplasm.