ESR1 and breast cancer: Thus, rs3732568 in EPHB1 showed a similar influence on either type of breast cancer (Table 3)–which is consistent with an overall significant association–and rs12765929 in BMPR1A and rs9836340 in EPHA3 showed a potential major impact on the risk of ERα-negative breast cancer (P for difference in OR (interaction) by ERα status <0.05), while rs4707795 in EPHA7 showed a differential effect between ERα-negative versus ERα-positive breast cancer risk (Pinteraction = 0.007) (Table 3).