A contribution of continually stimulated effector memory CD4+ T cells to parasite control and regulation of pathology are very much in line with observations that the best protection of humans in areas of endemic malaria is a certain level of continuous exposure [2], [37], and with the association of effector memory cells producing multiple cytokines observed in humans experimentally infected with P. falciparum sporozoites [40]. This evidence concerns the gene CD4 and malaria.