In addition, we cultured SV2B and SV2A/B KO spinal cord neurons and observed that while SV2B KO mice were still sensitive to the addition of TeNT, SV2A/B double KO spinal neurons were protected from TeNT; again the neurons were re-sensitized to the toxin after infection with SV2A virus (Figure 5D). The gene discussed is SV2B; the disease is infection.