It is proposed that this abnormality may be due to improper interactions between developing thymocytes and thymic stromal cells mediated by elevated levels of LFA-1 and ICAM-1 and an abnormal distribution of ICAM-1 in DS thymi that is then exacerbated by the expression of TNF and IFN-γ in DS thymi [60]. The gene discussed is TNF; the disease is Dravet syndrome.