Distribution of the −1195 and −765 COX-2 genotypes in both patient and control groups fitted the Hardy Weinberg equilibrium; for the −1195 genotypes, p-values of p = 0.14, p = 0.17 and p = 0.99, for the patients with Crohn's disease, ulcerative colitis and controls were found; whereas corresponding p-values for the −765 genotypes were p = 0.64, p = 0.26 and p = 0.87, respectively. This evidence concerns the gene PTGS2 and Crohn disease.