The link has been demonstrated in mice genetically deficient in Muc2 (C57BL/6J×129/SvOla Muc2−/−), a mucin gene expressed only in differentiated cells of the intestine, where impaired cell differentiation via Muc2 led to spontaneous development of adenomas along the entire gastrointestinal tract [39], [40], a pathology where excessive cells remained proliferative. This evidence concerns the gene MUC2 and adenoma.