MECP2 and Rett syndrome: Interestingly, expression of methyl CpG–binding protein 2 (MeCP2) is also tightly regulated by miR132 [18], and altered expression of MeCP2 has been shown to be an underlying element in the development of Rett syndrome, a neuro-developmental disorder in which dendritic development and synaptogenesis are affected [19]–[21].