Therefore, we clearly proved that Jak2/Stat3 together with the well characterized IL-6 downstream MEK/Erk, PI3-K/Akt and NF-κB pathways, jointly and differentially, regulates the autocrine production of IL-6 in a broad spectrum of established cancer cell lines as well as in clinical lung cancer samples. The gene discussed is AKT1; the disease is lung carcinoma.