Consistent with previous literature [30,39], we found that drug resistant cancer cells secreted more IL-6 secretion than the parental cells (Figures 6 and 7), and not only NF-κB, PI3-K/Akt and MEK/Erk but also Jak2/Stat3 pathway contributed to the autocrine production of IL-6 in these cells. This evidence concerns the gene MAPK1 and cancer.