GJB2 and hearing loss disorder: Through genotype and phenotype analysis in 1093 cases of unrelated, nonsyndromic Chinese individuals with hearing loss, GJB2 mutations were detected in 24.67% (130/527) of patients with bilateral profound hearing loss, 22.33% (44/197) with bilateral severe hearing loss, 14.33% (42/293) with bilateral moderate hearing loss, and 6.58% (5/76) with bilateral mild hearing loss (unpublished data).