Although mutations in Fbxw7/hCdc4 are frequent events in diverse tumor types, including endometrial carcinomas, cholangiocarcinomas, colorectal cancer and T-cell acute lymphoblastic leukemia [4,7,11,15,16], mutations are uncommon or absent in other malignancies [4,17]. The gene discussed is FBXW7; the disease is cholangiocarcinoma.