Subdividing these LNN tumors at the median level of ESR2 into high and low revealed that, in contrast to ESR1, increasing levels of DC-SCRIPT were, in both univariate and multivariable analyses, associated with good prognosis only for patients with primary tumors with low levels of ESR2. With respect to tumor size, in univariate and multivariable analyses, increasing levels of DC-SCRIPT were associated with good prognosis only for pT1 (small tumor without lymphatic/vascular invasion) tumors and not for larger tumors. Here, ESR1 is linked to neoplasm.