ESR1 and neoplasm: Because the proportional hazards assumptions were violated by ESR1 and tumor size and because DC-SCRIPT is a transcriptional co-regulator of nuclear receptors - including the, for breast cancer biologically relevant, steroid hormone receptors - we next explored its prognostic value as continuous variable in subgroups of tumors stratified by steroid hormone receptor status and tumor size (Table 3 and Figure 1).