When added to a multivariable base model for LNN disease - which included the traditional prognostic factors of age, menopausal status, grade, and PGR - stratified by ESR1 and tumor size to meet the proportional hazards assumption, the association of DC-SCRIPT with MFS remained highly significant (HR 0.60; P <0.001) (Table 2). Here, ESR1 is linked to neoplasm.