Although the precise function of CARD-8 is not clear, it was suggested that it may function as an adaptor molecule regulating caspase-1 activation (IL-1 β production), NF-κB activation and apoptosis.[49] Therefore, Fas/FasL and caspase-mediated apoptosis in silicosis not only provide clues for the pathogenesis and treatment of immunological disorders but also aid in predicting the preclinical status of complicated autoimmune diseases found in occupational disease. The gene discussed is NFKB1; the disease is autoimmune disease.