Interestingly, the del(GJB6-D13S1830) allele is the most frequent in Spain, France, the United Kingdom, Israel, and Brazil, accounting for 5.0–9.7% of all the DFNB1 alleles [62,90] and this finding provided an explanation for the deafness in as many as 30% to 70% of affected GJB2 heterozygotes in those countries. Here, GJB6 is linked to deafness.