It will be also of importance to further explore the frequency of GLI1 codon 1100 polymorphism in other human diseases, such as cancers, given the interesting fact that the GLI1 E1100 variant is carried by the two GBM cell lines (D-259 MG and U87MG) that have been genotyped thus far [1, 14]. The gene discussed is GLI1; the disease is glioblastoma.