AQP4 and Stroke: The experimental data on AQP4 regulation from mouse stroke models are contradictory; some studies reporting significant upregulation after 30 min MCA occlusion and 1-48 h reperfusion [78] and others describing a decrease in AQP4 immunoreactivity following longer MCA occlusion, indicating that its loss post stroke may require a critical duration or severity of ischemic injury.