It has been reported that ROCK-1 is over-expressed in brain tumour (Oellers et al, 2009) and related to metastasis in rat MM1 hepatoma cells, bladder, lung and prostate cancer (Itoh et al, 1999; Kamai et al, 2003; Chen et al, 2008; Lin et al, 2008). Here, ROCK1 is linked to Familial prostate cancer.