These previous studies showed that α-TEA induces apoptosis in human breast cancer cells via activation of proapoptotic extrinsic death receptor Fas and DR5 as well as activation of a JNK/p73/Noxa pathway, leading to activation of caspase-8 and mitochondrial-dependent apoptosis (Shun et al, 2004; Wang et al, 2008; Yu et al, 2010). The gene discussed is PMAIP1; the disease is breast cancer.