c-Jun N-terminal kinase, a proapoptotic mediator, has been reported to be activated by α-TEA and involved in α-TEA-induced Fas and Fas L protein expression in prostate cancer (Jia et al, 2008b), as well as p73/Noxa protein expression (Wang et al, 2008) and CHOP/DR5 protein expression (Tiwary et al, 2010) in breast cancer cells. The gene discussed is PMAIP1; the disease is prostate cancer.