Treatment of HCC-1954 (20 μM) and MCF-7 cells (40 μM) with α-TEA for 9, 15, and 24 h: (1) reduces levels of pAKT (both Ser-473 and Ser-308) as well as its downstream substrates pGSK (α/β) (Ser-21/9), pBad (Ser-136), and pcaspase-9 (Ser-196) and increases cleaved caspase 9 in a time-dependent manner (Figure 2A), (2) downregulates pERK1/2 and its substrates pp90SK (Ser-380) and pBad (Ser-112) (Figure 2B), and (3) downregulates pmTOR (Ser-2448) and its substrates pp70S6K (Thr-389) and p4E-BP1 (Thr-37/46) (Figure 2C). The gene discussed is CASP9; the disease is hepatocellular carcinoma.