Consistent with alleviation of neuropathic pain [11], VPC32183, a LPA1 and LPA3 receptors antagonist, blocked LPA-induced potentiation of TRPV1 currents in DRG neurons, mechanical allodynia and thermal hyperalgesia in bone cancer rats, suggesting that activation of LPA1 receptors mediates bone cancer-induced sensitization of DRG nociceptive neurons and pain hypersensitization. The gene discussed is TRPV1; the disease is bone cancer.