Our aim was to define: i) the expression pattern of PDGF-B and VEGF-A in tumor cells and activation of PDGFR-β tyrosine kinases in stromal cells of human gastric adenocarcinoma; and ii) the relationship between VEGF-A and PDGF-B expression and MVD, to determine whether there is a rationale for a new therapeutic strategy. This evidence concerns the gene PDGFRB and neoplasm.