SBNO2 and gastrointestinal disease: In this case (HP13), the deletion affected the 5' genes SBNO2 and GPX4, but did not reach the next upstream gene POLR2E. The gene SBNO2, a component of the IL-10-mediated anti-inflammatory pathway [37] has currently no known association with gastrointestinal diseases [33], but it was affected together with STK11 in several cell lines investigated [38,39].