SMARCA4 and neurodegenerative disease: The two most enriched signatures in the downregulated gene population (Figure 9) contained genes classified as "nervous system development" and "neurodegenerative diseases" with 37% (111 of 300) and 42% (14 of 33) respective signature enrichment, suggestive of disruption of Brg1-dependent programs associated with neural development as reported previously [10].