In addition, Leeman-Neill et al., [23] recently showed GS-treatment decreased the expression of both pSTAT3 (p-tyr-705), total STAT3 and hypoxia-inducible factor (HIF)-1α in HNSCC cell lines and in a xenograft model of HNSCC. This evidence concerns the gene STAT3 and head and neck squamous cell carcinoma.