APOB and coronary artery disorder: When assessing the efficacy of cholesterol-lowering therapy, including escalation of cholesterol-lowering therapy as demonstrated in this trial, most CHD outcomes evidence suggests that clinicians should focus on more established efficacy parameters, such as the reduction in the cholesterol carried by LDL particles, atherogenic lipoprotein particle concentration (approximated by apo B), and non-HDL-C levels.