Known molecular features characteristic for BRCA1-mutated breast tumors are 1) a high degree of genomic instability due to homologous recombination (HR) deficiency [18], 2) a distinct pattern of genomic aberrations [19-22] 3) a high frequency of TP53 mutations and 4) a high incidence of complex, protein-truncating TP53 mutations [10,23]. The gene discussed is BRCA1; the disease is breast neoplasm.