HIF1A and neoplasm: As far as the problems associated with HIF are concerned, Semenza (2002) suggested that the combination of an anti-angiogenic agent and an inhibitor of HIF-1 might be particularly efficacious, as the angiogenesis inhibitor would cut off the tumor’s blood supply and the HIF-1 inhibitor would prevent the ability of the tumor to adapt to the ensuing hypoxia and thus the efficacy of HIF inhibitor may be greatly enhanced [36].