Suppression of p53 in TRF1Δ/ΔK5-Cre mice rescues perinatal survival (p53−/−/TRF1Δ/ΔK5-Cre mice reach four months of age) and the functionality of epidermal stem cells, as these mice grow hair normally and do not exhibit skin hyperpigmentation [34]. Here, TP53 is linked to neoplasm.