GCKR and type 2 diabetes mellitus: We found no relationship between variants of GCKR gene and total serum cholesterol levels, however HDL-cholesterol level was significantly lower in subjects homozygous for the minor allele for both rs780094 and rs1260326, but only in T2DM patients, moreover LDL-cholesterol was significantly elevated in homozygous patients, but only in the MS group.