NCBI Entrez gene database [16] reported that: CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor, and associated with GBM; GSTM5 was reported to be involved in cancer, BCL11A is a proto-oncogene, and FN1 is involved in tumor metastasis and angiogenesis. The gene discussed is CHEK2; the disease is glioblastoma.