However, the most striking and frequent deletions occur between the 5 and 10Mb coordinates on 1p36.23, centering on the candidate tumor suppressor ERRFI1. Deletion of ERRFI1 has been reported to activate EGFR and sustain MAPK signaling, resulting in tumor phenotypes in numerous tissues in ERRFI1 knockout mice [43-45]. Here, ERRFI1 is linked to neoplasm.