Further, enhancing muscle insulin sensitivity in human and animal models of obesity and diabetes, through the use of insulin sensitizers, such as PPAR-β/δ agonists, and the thiazolidinediones and SIRT1 modulators, such as Resveratrol, has been successful in restoring skeletal mitochondrial regulation and insulin sensitivity [31–33]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.