It has been concluded that (1) assessment of serum AAbs to BRCA1 protein alone is of no value for screening and early diagnosis of breast carcinoma, (2) serum AAbs to BRCA1 have no diagnostic potential even if incorporated in AAb assays against a panel of TAAs, (3) assessment of serum AAbs to BRCA2 protein alone is of little value for screening and early diagnosis of breast carcinoma, and (4) serum AAbs to BRCA2 may have, however, promising diagnostic potential when incorporated in AAb assays against a panel of TAAs [23]. This evidence concerns the gene BRCA2 and breast carcinoma.