Patients with type 2 diabetes receiving subcutaneously a daily dose of 100 mg of anakinra, a recombinant human IL-1ra, for 13 weeks show a significant decrease in glycated hemoglobin level and fasting blood glucose, ratio of serum proinsulin to insulin, and IL-6 and C-reactive protein levels while show an increase in serum C-peptide level [42, 43]. This evidence concerns the gene INS and type 2 diabetes mellitus.