OPA1 and autosomal dominant optic atrophy: The majority (50–60%) of patients with DOA harbour mutations in the OPA1 gene (OMIM 165500), and over 200 pathogenic mutations have been identified (eOPA1 database at http://lbbma.univ-angers.fr/lbbma.php?id=9, Accessed 31st of August 2010) (Table 4).