In addition, the type 1 IFN related genes (OAS1G, OAS2, OASL1, OASL2, S100A6, S100A8, S100A9, S100A11) that are necessary for activation of the inflammasome in Francisella novida-infected macrophages [22], were highly induced over the course of infection and peaked at 24 hpi. This evidence concerns the gene S100A6 and infection.