Additionally, given that there is no difference in vascular density in xenograft tumors derived from injection of Mena Null and Mena WT cells obtained from PyMT animals or in xenografts derived from MTLn3 Mena overexpressing cells, we conclude that the decrease in intravasation observed in both transgenic PyMT Mena Null mice and in Mena Null xenograft mice is the result of a Mena deficiency in tumor cells leading to a change in their intravasation phenotype and is not due to changes in vascular density. Here, ENAH is linked to neoplasm.