Very interestingly, there is also a switch between FGFR1 and another FGFR member FGFR3. The gene expressions between FGFR1 and FGFR3 were observed as mutually exclusive in colorectal carcinoma cells and indicated that their reciprocal relationship plays an important role in the progression of the carcinomas [26]. Here, FGFR3 is linked to carcinoma.