The opposite expression pattern of DLX2 and DLX5 in tumors are also consistent with previous observations, showing that DLX2 is expressed at higher levels in tumor cell lines which are more sensitive to apoptotic induction by fenretinide, whereas DLX5 and DLX6 appear to segregate in a distinct functional compartment [28]. The gene discussed is DLX5; the disease is neoplasm.