Besides DAPK1, 5-Aza and DNMT1 antisense oligonucleotides are able to restore the sensitivity of cancer cells to IFN-triggered apoptosis despite the re-expression of the pro-apoptotic gene RASSF1A and XAF1 which are frequently silenced by epigenetic mechanisms [137,138]. This evidence concerns the gene RASSF1 and cancer.