In fact, a lower CXCR4 MFI ratio was found in diseases where the presence of circulating neoplastic B cells is less frequent (WM and DLBC), and a higher ratio was found in NHL types associated with the presence of circulating neoplastic B cells in a larger frequency of cases (FL and CLL). This evidence concerns the gene CXCR4 and B-cell chronic lymphocytic leukemia.