In a previous report, we have shown that IL-4 DCs from multiple myeloma patients can be functionally improved through upregulation of the chaperone protein calnexin, which substantially increases the secretion of inflammatory cytokines and chemokines accompanied by a strong memory T cell response [31,35]; DCP-DCs, as illustrated here, may accomplish the same without further modifications. Here, CANX is linked to AL amyloidosis.